Reliability of steroid radioimmunoassays.
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Reliability of steroid radioimmunoassays.

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Published by (Uppsala University) in Uppsala .
Written in English


Book details:

Edition Notes

SeriesActa universitatis upsaliensis -- 14
ID Numbers
Open LibraryOL21736484M
ISBN 109155404154

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In book: Steroid Analysis (pp) of mass spectrometric techniques for analysis of corticosteroids in animals produced as food. samples for improving reproducibility and reliability. Estimation of true values in radioimmunoassay. strate the validity of a series of steroid radioimmunoassays, in order to make possible an assessment of reliability of the method. Biases. Abstract. Radioimmunoassay (RIA) is currently one of the most widely applied of all immunoassay procedures. The increasing application of this technique in many routine clinical diagnostic tests has resulted in requirements for improved reliability and reproducibility, greater rapidity and . Testosterone is a steroid hormone. Other steroids in the body include cholesterol, bile acids, vitamin D, and hormones of the adrenal glands and ovary. The majority of circulating testosterone in men comes from production in the interstitial cells of Leydig at the testicles.

Die Entwicklung des Radioimmunoassays (RIA) geht auf Untersuchungen von Yalow und Berson [1, 2] in den fünfziger Jahren zurück. Ihnen gelang die Bestimmung von Insulin im Serum unter Verwendung von Antikörpern gegen Insulin und J-Insulin, das mit dem nicht markierten Insulin um die Bindungsplätze am Antikörper konkurrierte. Since the symptoms of hypogonadism may be nonspecific, and the signs of testosterone deficiency can be subtle and slow to develop, the assessment of testicular function relies heavily on laboratory testing. The laboratory diagnosis of hypogonadism is based on a consistent unequivocally low serum total testosterone level, but normal ranges vary with different methods and among laboratories. R Malvano, E Rolleri, U Rosa. Standardization and control of steroid radioimmunoassays. In: Radioimmunoassay and Related Procedures in Medicine, Vol II. Vienna: International Atomic Energy Agency, , p JJ Pratt, MG Woldring. Radioimmunoassay specificity and the ''first-come, first-served effect.'' Clin Chim Acta , A Jacklitsch. Cholesterol, triglycerides, and high-density lipoproteins are important constituents of the lipid fraction of the human body. Cholesterol is an unsaturated alcohol of the steroid family of compounds; it is essential for the normal function of all animal cells and is a fundamental element of their cell membranes. It is also a precursor of various critical substances such as adrenal and gonadal.

endocrine monitoring of reproduction and stress. items to an animal is another way to collect saliva samples. Samples should be frozen aft er collection, and most assays require fairly extensive extraction procedures. Some com-mercial companies have developed assays specifi c for saliva to avoid problems associated with matrix eff ects. Urine. The established approach to the evaluation of ovarian function and endocrine disorders in the woman is based on serial biochemical analyses of hormones, such as estrogen, progesterone, luteinizing hormones and their metabolites (Albertson and Zinaman, ).More recently, the analysis of hormonal substances that participate in embryonal development of gonads has contributed still further to. Schirpenbach C, Seiler L, Maser-Gluth C, Beuschlein F, Reincke M, Bidlingmaier M. Automated chemiluminescence-immunoassay for aldosterone during dynamic testing: comparison to radioimmunoassays with and without extraction steps. Clin Chem ;– On the occasion of the 50th anniversary of the American Association for Clinical Chemistry, Dr. Thomas Annesley, Book Reviews Editor of Clinical Chemistry, felt that a review of clinical chemistry textbooks covering the past three decades would enable the younger generation of clinical chemists to appreciate the profound changes that have taken place in the clinical chemistry laboratory.